Poly ADP Ribose Polymerase 14 (PARP14)

Poly(ADP-ribosyl)ation is an immediate DNA damage-dependent posttranslational modification of histones and other nuclear proteins that contributes to the survival of injured proliferating cells. PARP14 belongs to the superfamily of enzymes that perform this modification. RT-PCR ELISA detected intermediate to high expression in all tissues and specific brain regions examined. Highest levels were in lung, liver, kidney, spleen, and fetal liver.the full-length PARP14 protein contains 1,518 amino acids and has a calculated molecular mass of 170.6 kD. It contains 2 central domains similar to the C-terminal domain of the macroH2A histone protein (H2AFY) and a C-terminal region containing a WWE domain, which is found in proteins associated with ubiquitination, followed by a catalytic domain.