Polymerase DNA Directed Delta 3 (POLD3)

The DNA polymerase delta complex is involved in DNA replication and repair, and it consists of the proliferating cell nuclear antigen, the multisubunit replication factor C, and the 4 subunit polymerase complex: POLD1, POLD2, POLD3, and POLD4.

POLD3 contains 491 amino acids. Northern blot analysis detected high expression in lung, kidney, testis, and colon, moderate expression in placenta, skeletal muscle, and ovary, and low expression in heart, brain, liver, pancreas, spleen, thymus, prostate, small intestine, and peripheral blood leukocytes.The protein has a calculated molecular mass of 51.4 kD but migrates as a 66-kD protein. It contains a proline-rich region, a C-terminal PCNA-binding domain, and a bipartite nuclear localization signal.