Polymerase DNA Directed Epsilon 1 (POLe)

DNA polymerase epsilon (EC 2.7.7.7) is 1 of the 4 nuclear DNA polymerases in eukaryotic cells. The mammalian enzyme is involved in DNA repair and possibly also in replication of chromosomal DNA. For additional background information on DNA polymerases. Szpirer et al. (1994) assigned the gene for the large subunit of POLE to chromosome 12 in both human and rat by Southern blot analysis of genomic DNA from mouse/human and mouse/rat somatic cell hybrid panels using a human cDNA probe. The human gene was then regionally localized to 12q24.3 by fluorescence in situ hybridization. POLE is closely linked to the gene for hepatocyte nuclear factor-1 (HNF1A), a hepatic transcription factor. The 2 genes define a synteny group retained on human and rat chromosomes 12.