Popeye Domain Containing Protein 3 (POPDC3)

Using a differential cloning strategy to identify transcripts preferentially expressed during chick heart development, Andree et al. (2000) isolated a chicken cDNA clone, which they called POP1, homologous to the previously identified human BVES. Using the chicken POP1 clone to initiate cDNA library screening and database searches for mammalian orthologs, Andree et al. (2000) identified mouse and human POP3. Human POP3 encodes a deduced 292-amino acid, 37-kD protein containing 3 predicted N-terminal transmembrane helices. It shares sequence similarity with the related family members BVES and POP2.Northern blot analysis detected POP3 transcripts of 1.8 and 1.6 kb in human skeletal muscle and heart. In situ hybridization demonstrated POP3 expression in the developing heart of chicken.