Potassium Channel Subfamily K, Member 5 (KCNK5)

KCNK5 is highly sensitive to external pH and this, in combination with its expression pattern, suggests it may play an important role in renal potassium transport.TASK2 has all the hallmarks of a 2P domain potassium channel, but shows only 18 to 22% amino acid identity with other 2P domain potassium channels. COS cells expressing TASK2 displayed nonactivating currents, and the current-voltage relationship was outwardly rectifying. Like TASK1 currents, TASK2 currents were highly sensitive to extracellular pH in the physiologic range. TASK2 transcript that was expressed abundantly in kidney and to a lesser extent in the pancreas, liver, placenta, and small intestine. In situ hybridization of human kidney localized TASK2 mRNA to the cortical distal tubules and collecting ducts.