Potassium Channel Tetramerisation Domain Containing Protein 1 (KCTD1)

The deduced 257-amino acid protein contains an N-terminal tetramerization domain, which is a variant of a BTB-type protein-interaction domain, and has a predicted molecular mass of 29.4 kD. A minor 4.0-kb transcript was detected in mammary gland, kidney, brain, ovary, and lung.

KCTD1 expression was not detected in other tissues. Immunohistochemical analysis detected endogenous KCTD1 protein in a punctate distribution in nuclei of HeLa cells and a normal mammary epithelial cell line. Database analysis revealed that the KCTD1 protein is highly conserved: the mouse Kctd1 protein is identical to human KCTD1 except for an 8-amino acid insertion following the initiating methionine, and the rat and human proteins are identical except for 1 amino acid change.