Potassium Channel Tetramerisation Domain Containing Protein 11 (KCTD11)

Ren was upregulated by neurogenic signals, such as retinoic acid, EGF, and NGF (NGFB), in pluripotent mouse embryonic stem cells and in rat neural progenitor cell lines in association with neuronal differentiation. Ren overexpression induced neuronal differentiation, growth arrest, and p27(KIP1)expression in central and peripheral neural progenitor cell lines. Inhibition of Ren impaired retinoic acid induction of neurogenin-1 and NeuroD expression.The deduced 232-amino acid protein has an apparent molecular mass of 26 kD and contains an N-terminal BTB/POZ domain and several sites for N-myristoylation and phosphorylation. Northern blot analysis detected Ren expression in adult lung and day-7 mouse embryos. RT-PCR detected peak Ren expression at embryonic day 8.5, with decreasing levels thereafter.