Potassium Voltage Gated Channel Subfamily H, Member 8 (KCNH8)

KCNH8 belongs to the ELK subfamily of the EAG family of voltage-gated potassium channels. Channels of the EAG family likely function as tetramers.The deduced 1,107-amino acid protein contains all of the key features of an EAG family channel, including an N-terminal PAS domain, 6 transmembrane segments, a K+ channel pore motif, and a cyclic nucleotide-binding domain. Northern blot analysis and quantitative PCR detected expression primarily in the nervous system, with prominent expression in the forebrain. Expression was also detected in testis, but very little was detected in other nonneuronal tissues.Transfected cells showed a slowly activating, noninactivating, and slowly deactivating outward K+ current at depolarizing voltages from -30 mV to +50 mV.