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ITEM PROTEIN ANTIBODY ASSAY KIT CELL
Presenilin 1 (PSEN1)
FAD; AD3; PS1; S182; Alzheimer Disease 3
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma secretase activity or themselves are protease enzymes. Multiple alternatively spliced transcript variants have been identified for this gene, the full-length natures of only some have been determined.
Organism species: Homo sapiens (Human)
CATALOG NO. PRODUCT NAME
Proteins RPC200Hu01 Recombinant Presenilin 1 (PSEN1) Customize
Antibodies MAC200Hu21 Monoclonal Antibody to Presenilin 1 (PSEN1) Customize
PAC200Hu01 Polyclonal Antibody to Presenilin 1 (PSEN1) Customize
Assay Kits SEC200Hu ELISA Kit for Presenilin 1 (PSEN1) In Stock
SCC200Hu CLIA Kit for Presenilin 1 (PSEN1) Customize
Organism species: Mus musculus (Mouse)
CATALOG NO. PRODUCT NAME
Proteins RPC200Mu01 Recombinant Presenilin 1 (PSEN1) Customize
Antibodies PAC200Mu01 Polyclonal Antibody to Presenilin 1 (PSEN1) Customize
MAC200Mu21 Monoclonal Antibody to Presenilin 1 (PSEN1) Customize
Assay Kits SEC200Mu ELISA Kit for Presenilin 1 (PSEN1) Customize
SCC200Mu CLIA Kit for Presenilin 1 (PSEN1) Customize
Organism species: Rattus norvegicus (Rat)
CATALOG NO. PRODUCT NAME
Proteins RPC200Ra01 Recombinant Presenilin 1 (PSEN1) Customize
Antibodies MAC200Ra21 Monoclonal Antibody to Presenilin 1 (PSEN1) Customize
PAC200Ra01 Polyclonal Antibody to Presenilin 1 (PSEN1) Customize
Assay Kits SEC200Ra ELISA Kit for Presenilin 1 (PSEN1) In Stock
SCC200Ra CLIA Kit for Presenilin 1 (PSEN1) Customize