Progesterone Receptor Membrane Component 2 (PGRMC2)

Using the sequence of a porcine progesterone receptor as probe, Gerdes et al. (1998) cloned PGRMC2, which they designated DG6. The deduced protein contains 223 amino acids and has an N-terminal hydrophobic region. It has no N-glycosylation site. PGRMC2 shares about 50% identity overall with PGRMC1, and they share 68% identity in their C termini, including a highly conserved 58-amino acid sequence. Northern blot analysis revealed expression of 2.0-kb transcripts in all tissues examined, with highest expression in placenta.

Transcripts of 3.0 and 5.0 kb were also detected.By genomic sequence analysis, Gerdes et al. (1998) mapped the PGRMC2 gene to chromosome 4q26.