Programmed Cell Death Protein 10 (PDCD10)

PDCD10 encodes a protein, originally identified in a premyeloid cell line, with similarity to proteins that participate in apoptosis. Three alternative transcripts encoding the same protein, differing only in their 5' UTRs, have been identified for this gene.PDCD10 cDNA was originally cloned on the basis of its upregulated expression in the human myeloid cell line TF-1, in which apoptosis was induced by deprivation of granulocyte macrophage colony-stimulating factor (CSF2), and that PDCD10 cDNA and genomic structures were reported in several genome databases with more than 150 reported ESTs. The coding portion of the cDNA is 636 bp long and encodes a 212-amino acid predicted protein. Three alternative transcripts that differed only in their 5-prime untranslated regions had been identified.