Prolactin Regulatory Element Binding Protein (PREB)

SEC12; Mammalian guanine nucleotide exchange factor mSec12

Prolactin Regulatory Element Binding Protein (PREB)
PREB may act as a transcriptional regulator and is thought to be involved in some of the developmental abnormalities observed in patients with partial trisomy 2p. This gene overlaps the abhydrolase domain containing 1 (ABHD1) gene on the opposite strand.The deduced 417-amino acid protein, which is 89% identical to the rat protein, has 3 conserved WD repeats and 2 conserved pro-gln-rich regions. RNA dot blot analysis detected variable expression of PREB in all adult and fetal tissues. They proposed that PREB is a DNA-binding factor during mammalian development and that abnormal dosage may play a role in some of the phenotypic abnormalities observed in the partial trisomy 2p syndrome, which is characterized by a number of congenital defects, including genital abnormalities.

Organism species: Homo sapiens (Human)

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Organism species: Mus musculus (Mouse)

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Organism species: Rattus norvegicus (Rat)

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