Proline Synthetase Co Transcribed Homolog (PROSC)

Since the P. aeruginosa homolog of this novel gene is located upstream of and may be cotranscribed with a known proline biosynthetic gene, the authors called the human gene PROSC, for 'proline synthetase cotranscribed, bacterial homolog.' The PROSC gene spans 17.2 kb and contains 8 exons. It is oriented in a 5-prime to 3-prime direction from telomere to centromere. Northern blot analysis detected a 2.6-kb PROSC transcript that was expressed in all human adult and fetal tissues tested. The deduced 275-amino acid PROSC protein shares 86.5% sequence identity with mouse Prosc and 28% identity with its P. aeruginosa homolog. PROSC is predicted to be a soluble, cytoplasmic protein. It contains a putative N-linked glycosylation site and a putative cAMP- and cGMP-dependent protein kinase phosphorylation site.