Proteasome 26S Subunit, Non ATPase 11 (PSMD11)

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. PSMD11 encodes a non-ATPase subunit of the 19S regulator. The predicted 422-amino acid protein has 9 dileucine repeats, possible coiled-coil domains, and potential myristylation and phosphorylation sites. PSMD11 is not a member of the ATPase family. Whereas the calculated molecular mass of PSMD11 is 47,469 Da, it migrates as an approximately 46-kD protein on SDS-polyacrylamide gels.