Protein Kinase, Membrane Associated Tyrosine/Threonine 1 (PKMYT1)

PKMYT1 is a member of the serine/threonine protein kinase family. This kinase preferentially phosphorylates and inactivates cell division cycle 2 protein (CDC2), and thus negatively regulates cell cycle G2/M transition. This kinase is associated with the membrane throughout the cell cycle. Its activity is highly regulated during the cell cycle. Protein kinases AKT1/PKB and PLK (Polo-like kinase) have been shown to phosphorylate and regulate the activity of this kinase. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

The MYT1 cDNA encodes a predicted 499-amino acid polypeptide with a molecular mass of 55 kD. localizes to the endoplasmic reticulum and Golgi complex in HeLa cells.