Protein Phosphatase, Mg2+/Mn2+ Dependent 1G (PPM1G)

PPM1G is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome.

The deduced 546-amino acid PPM1G protein contains the highly conserved signature sequences of PP2C phosphatases, suggesting that it is a member of the PP2C family. However, PPM1G shares only 34% amino acid sequence identity with human PP2C-alpha. A distinctive feature of PPM1G is the presence of a large acidic domain. PPM1G also contains putative PEST sequences, numerous potential sites for phosphorylation, and a possible myristylation site.