Protein Phosphatase 2, Regulatory Subunit B'' Gamma (PPP2R3C)

G5PR is capable of recruiting two kinds of PPases, PP5 and PP2A, into the GANP/MCM3 complex, which might regulate its phosphorylation state during cell cycle progression.G5PR is associated with protein phosphatase 5 through its tetratricopeptide-repeat domain. G5PR is also associated with protein phosphatase 2A, the complex of A subunit and the catalytic (C) subunit, similar to the B" subunit. The G5PR-associated complex had phosphatase activity on casein, histone H1 and MCM3 in vitro, but the addition of G5PR did not stimulate or inhibit the phosphatase activities of PP5 and PP2A. The cellular localization of G5PR in transfected cells varies during cell cycling, appearing in the nucleus during prophase, in the peri-chromatin during mitotic phase, and in the cytoplasm after cell division.