Pseudouridylate Synthase 7 Like Protein (PUS7L)

PUS7L belongs to the pseudouridine synthase truD family. PUS7L was used as a reference gene because of its extremely stable mRNA expression in all samples, and no previous indications of amplification in cancer. Pseudouridylate synthase 7 homolog (PUS7L) was chosen as a reference gene because of its extremely consistent expression across all study samples and no known links with cancer, therefore making it unlikely that it was amplified in any of the samples.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is uracil hydro-lyase (adding D-ribose 5-phosphate pseudouridine-5'-phosphate-forming). This enzyme participates in pyrimidine metabolism.