Putative Homeodomain Transcription Factor 1 (PHTF1)

Homeodomain-containing proteins are transcriptional regulators. The homeodomain is a 60-amino acid sequence that adopts a helix-turn-helix structure.

To identify genes regulated during hematopoietic differentiation, Raich et al. (1999) constructed a subtracted cDNA library using mRNAs isolated from human erythroleukemic cells cultured in the presence or absence of 12-O-tetradecanoylphorbol-13-acetate. They identified a cDNA encoding PHTF1, which they referred to as PHTF. The predicted 763-amino acid PHTF1 protein contains an atypical homeodomain.By in situ hybridization, Raich et al. (1999) mapped the PHTF1 gene to 1p13.