Pyrimidinergic Receptor P2Y, G Protein Coupled 4 (P2RY4)

P2Y purinoceptor 4 is a protein belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to uridine nucleotides, partially responsive to ATP, and not responsive to ADP.

The encoded protein, UNR, has greatest overall identity (54%) with human P2U purinoceptor (P2RY2). The greatest degree of amino acid identity occurs within the putative 7-transmembrane domain, where it demonstrates 74% identity. Dendrogram analysis of the G protein-coupled P2 purinoceptors and UNR indicated that these receptors belong to a family that may be more aptly named nucleotide receptors.