Pyrin And HIN Domain Family, Member 1 (PYHIN1)

PYHIN1 belongs to the HIN200 family of interferon-inducible proteins that share a 200-amino acid signature motif at their C-terminal ends. HIN200 proteins are primarily nuclear and are involved in transcriptional regulation of genes important for cell cycle control, differentiation, and apoptosis .

The IFIX-alpha-2, -beta-2, and -gamma-2 isoforms lack 9 amino acids in their N-terminal regions relative to IFIX-alpha-1, -beta-1, and -gamma-1. IFIX-alpha and -beta isoforms have the type A C-terminal 200-amino acid signature motif of HIN200 proteins, including the conserved sequence MFHATVAT, whereas the IFIX-gamma isoforms lack the 200-amino acid signature sequence. The common N-terminal region of IFIX contains a predicted pyrin (MEFV) protein-protein interaction domain and a nuclear localization signal.