Pyrophosphatase 2 (PPA2)

Pyrophosphatase 2 is localized to the mitochondrion, is highly similar to members of the inorganic pyrophosphatase (PPase) family, and contains the signature sequence essential for the catalytic activity of PPase. PPases catalyze the hydrolysis of pyrophosphate to inorganic phosphate, which is important for the phosphate metabolism of cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

The deduced 334-amino acid protein has a calculated molecular mass of 38 kD. PPA2 shares about 60% amino acid identity with PPA1, and it has a 31-amino acid N-terminal extension not found in PPA1 that functions as a mitochondrial import signal.