RAB GTPase Activating Protein 1 Like Protein (RABGAP1L)

RABGAP1L expression was upregulated in esophageal squamous cell carcinomas compared with matched normal esophageal epithelial tissue. In particular, RABGAP1L expression was upregulated in esophageal tumors showing nodal invasion.

The deduced 298-amino acid protein contains a PTB domain and shares homology with the N terminus of human GAPCENA (RABGAP1). Northern blot analysis detected several Rabgap1l transcripts expressed in a tissue-specific manner. In situ hybridization of day-14.5 embryos revealed expression in heart and liver.The deduced protein contains 370 amino acids. SDS-PAGE detected RABGAP1L at an apparent molecular mass of about 50 kD.