RAB24, Member RAS Oncogene Family (RAB24)

RAB24 is a small GTPase of the Rab subfamily of Ras-related proteins that regulate intracellular protein trafficking. The deduced 203-amino acid RAB24 protein contains 4 highly conserved GTPase motifs and a C-terminal geranylgeranylation motif. Highest expression was detected in pancreas, followed by heart and leukocytes. Low expression was detected in thymus, spleen, prostate, placenta, lung, liver, skeletal muscle, and kidney. Little to no expression was detected in brain, testis, ovary, small intestine, and colon.Rab24 has very low GTPase activity in intact cells, primarily due to the presence of a serine instead of a glutamine at position 61. Posttranslational geranylgeranylation of Rab24, which ends in a CCHH motif, is relatively inefficient when compared with other Rab proteins, which typically end with CXC or CC motifs.