RAB25, Member RAS Oncogene Family (RAB25)

RAB proteins, such as RAB25, are members of the RAS superfamily of small GTPases that are involved in membrane trafficking. Members of the RAB11 subfamily, including RAB25, control the return of internalized membrane-associated moieties to the cell surface.

The deduced 217-amino acid protein contains 4 highly conserved GTPase motifs and an unconventional C-terminal motif (CCISL) rather than the more common geranylgeranylation motif found in other RAB proteins. Northern blot analysis detected a major transcript of about 1.35 kb that showed highest expression in pancreas, followed by kidney, placenta, lung, prostate, small intestine, and colon. Little to no expression was detected in other tissues examined.