RAB2B, Member RAS Oncogene Family (RAB2B)

Members of the Rab protein family are nontransforming monomeric GTP-binding proteins of the Ras superfamily that contain 4 highly conserved regions involved in GTP binding and hydrolysis. Rab proteins are prenylated, membrane-bound proteins involved in vesicular fusion and trafficking.

The deduced 216-amino acid RAB2B protein shares 82% and 83% sequence identity with human RAB2 and mouse Rab2, respectively. RT-PCR analysis revealed expression of RAB2B in kidney, prostate, lung, liver, thymus, colon, pancreas, and skeletal muscle, and at lower levels in placenta. No transcript was detected in heart, brain, spleen, testis, ovary, small intestine, and leukocyte. Overexpression was observed in a colon adenocarcinoma.