RAD52 Motif Protein 1 (RDM1)

RDM1 encodes a protein involved in the cellular response to cisplatin, a drug commonly used in chemotherapy. The protein encoded by this gene contains two motifs: a motif found in RAD52, a protein that functions in DNA double-strand breaks and homologous recombination, and an RNA recognition motif (RRM) that is not found in RAD52. The RAD52 motif region in RAD52 is important for protein function and may be involved in DNA binding or oligomerization. Alternatively spliced transcript variants encoding different isoforms have been reported. Human RDM1 shares 71.1% and 51.2% amino acid identity with mouse and chicken Rdm1, respectively. RDM1 transcript in testis, but little to no expression was detected in spleen, thymus, prostate, ovary, small intestine, colon, and peripheral blood leukocytes.