RANBP2 Like And GRIP Domain Containing Protein 5 (RGPD5)

BS-63;RGP5; RGP3; RANBP2L1; RanBP2alpha; RGP6; NUP358; RANBP2L2; RGP2

RANBP2 Like And GRIP Domain Containing Protein 5 (RGPD5)
RGPD5 shares a high degree of sequence identity with RANBP2, a large RAN-binding protein localized at the cytoplasmic side of the nuclear pore complex. It is believed that this RANBP2 gene family member arose from a duplication event 3 Mb distal to RANBP2. Alternative splicing has been observed for this locus and two variants are described. Additional splicing is suggested but complete sequence for further transcripts has not been determined.
The RGPD genes resulted from duplications of a region of human chromosome 2 containing the RANBP2 and GCC2 genes. Like other RGPD proteins, the deduced RGPD5 protein exceeds 1,700 amino acids. Most of the sequence is homologous to regions of RANBP2, except for the C terminus, which includes the GRIP domain from GCC2.

Organism species: Homo sapiens (Human)