RB1 Inducible Coiled Coil Protein 1 (RB1CC1)

RB1CC1 interacts with signaling pathways to coordinately regulate cell growth, cell proliferation, apoptosis, autophagy, and cell migration. This tumor suppressor also enhances retinoblastoma 1 gene expression in cancer cells. The cDNA encodes a deduced 1,594-amino acid protein containing a consensus nuclear localization signal (KPRK), a leucine zipper motif, and a coiled-coil structure. The protein showed a molecular mass of 180 kD by Western blot analysis. Nuclear localization was confirmed by cell fractionation and immunocytochemistry analysis. The RB1CC1 protein is a key regulator of the tumor suppressor gene RB1. It is localized in the nucleus and has been proposed to be a transcription factor because of its nuclear localization signal, leucine zipper motif, and coiled-coil structure.