RELT Like Protein 2 (RELL2)

The predicted RELL2 sequence contains a transmembrane domain but lacks extracellular cysteine-rich domains. RELL2 shares 27% and 40% amino acid identity with RELT and RELL1, respectively. Northern blot analysis detected an approximately 3-kb transcript primarily in human immune-related tissues such as spleen, thymus, testis, peripheral blood leukocytes, and placenta.

RELL2 mRNA was not detected in prostate, ovary, small intestine, colon, heart, lung, liver, skeletal muscle, kidney, or pancreas. Immunofluorescent confocal microscopy localized RELL2 to the plasma membrane in COS-7 cells and colocalized RELL2 with RELL1 and RELT.RELL2 bound RELL1, RELT, and serine-threonine kinase OSR1 (OXSR1).