RNA Binding Motif Protein 10 (RBM10)

RBM10 contains RNA recognition motif found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. In vitro studies showed that the rat homolog bound to RNA homopolymers, with a preference for G and U polyribonucleotides. This gene is part of a gene cluster on chromosome Xp11.23, and its 3' end lies within 20 kb upstream of UBE1. Two transcript variants encoding different isoforms have been identified for this gene.Nagase et al. (1995) cloned an RNA-binding protein as part of a random sequencing project of cDNAs from a myeloid cell line. They termed KIAA0122, encodes a putative polypeptide of 880 amino acids that has significant homology with several RNA-binding proteins.