RNA Binding Motif Protein 12 (RBM12)

RBM12 encodes a protein that contains several RNA-binding motifs, potential transmembrane domains, and proline-rich regions. This gene and the gene for copine I overlap at map location 20q11.21. Alternative splicing in the 5' UTR results in two transcript variants. Both variants encode the same protein.The full-length cDNA encodes a deduced 932-amino acid protein with a calculated molecular mass of 97 kD. It contains 5 RNA-binding motifs, several potential transmembrane domains, and 2 proline-rich regions that coincide with 2 of the transmembrane domains. The RBM12 protein has a nuclear targeting sequence and a mitochondrial targeting sequence, but no signal sequence. Northern blot analysis detected abundant expression of a 3.5-kb transcript in all cell lines tested.