RNA Binding Protein With Multiple Splicing (RBPMS)

RBPMS encodes a member of the RRM family of RNA-binding proteins. The RRM domain is between 80-100 amino acids in length and family members contain one to four copies of the domain. The RRM domain consists of two short stretches of conserved sequence called RNP1 and RNP2, as well as a few highly conserved hydrophobic residues. The protein encoded by this gene has a single, putative RRM domain in its N-terminus. Alternative splicing results in multiple transcript variants encoding different isoforms.The single-copy RBPMS gene is alternatively spliced, resulting in at least 12 transcripts with an average length of 1.5 kb. Nine different types of cDNAs encoding an N-terminal RNA-binding motif homologous to that of the Drosophila 'couch potato' protein and C-terminal helix-rich sequences were identified.