RNA Polymerase II, DNA Directed Polypeptide G (POLR2G)

POLR2G encodes the seventh largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. In yeast, the association of this subunit with the polymerase under suboptimal growth conditions indicates it may play a role in regulating polymerase function.Southern blots of genomic and cloned DNA suggested that it is encoded by a single gene. The sequence of the 5-prime flanking region did not contain a TATA element, but did contain several Sp1-binding sites, an AP-1 site, and a novel inverted polymorphic GATA tandem repeat. The gene seemed to be highly conserved among eukaryotic species, showing general sequence conservation with yeast and Drosophila. Expression was relatively high in adult retina, brain, and kidney.