RNA Polymerase III, DNA Directed Polypeptide A (POLR3A)

RPC1; RPC155; hRPC155; RNA Polymerase III 155 kDa Subunit; DNA-directed RNA polymerase III subunit RPC1; DNA-directed RNA polymerase III largest subunit

RNA Polymerase III, DNA Directed Polypeptide A (POLR3A)
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition By similarity. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses.

Organism species: Homo sapiens (Human)

  • Customized Servicen/aRecombinant RNA Polymerase III, DNA Directed Polypeptide A (POLR3A)Recombinant Protein Customized Service Offer
  • Customized Servicen/aMonoclonal Antibody to RNA Polymerase III, DNA Directed Polypeptide A (POLR3A)Monoclonal Antibody Customized Service Offer
  • Customized Servicen/aPolyclonal Antibody to RNA Polymerase III, DNA Directed Polypeptide A (POLR3A)Polyclonal Antibody Customized Service Offer
  • Customized Servicen/aCLIA Kit for RNA Polymerase III, DNA Directed Polypeptide A (POLR3A)CLIA Kit Customized Service Offer
  • Customized Servicen/aELISA Kit for RNA Polymerase III, DNA Directed Polypeptide A (POLR3A)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

  • Customized Servicen/aRecombinant RNA Polymerase III, DNA Directed Polypeptide A (POLR3A)Recombinant Protein Customized Service Offer
  • Customized Servicen/aMonoclonal Antibody to RNA Polymerase III, DNA Directed Polypeptide A (POLR3A)Monoclonal Antibody Customized Service Offer
  • Customized Servicen/aPolyclonal Antibody to RNA Polymerase III, DNA Directed Polypeptide A (POLR3A)Polyclonal Antibody Customized Service Offer
  • Customized Servicen/aCLIA Kit for RNA Polymerase III, DNA Directed Polypeptide A (POLR3A)CLIA Kit Customized Service Offer
  • Customized Servicen/aELISA Kit for RNA Polymerase III, DNA Directed Polypeptide A (POLR3A)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

  • Customized Servicen/aRecombinant RNA Polymerase III, DNA Directed Polypeptide A (POLR3A)Recombinant Protein Customized Service Offer
  • Customized Servicen/aMonoclonal Antibody to RNA Polymerase III, DNA Directed Polypeptide A (POLR3A)Monoclonal Antibody Customized Service Offer
  • Customized Servicen/aPolyclonal Antibody to RNA Polymerase III, DNA Directed Polypeptide A (POLR3A)Polyclonal Antibody Customized Service Offer
  • Customized Servicen/aCLIA Kit for RNA Polymerase III, DNA Directed Polypeptide A (POLR3A)CLIA Kit Customized Service Offer
  • Customized Servicen/aELISA Kit for RNA Polymerase III, DNA Directed Polypeptide A (POLR3A)ELISA Kit Customized Service Offer