RNA Polymerase III, DNA Directed Polypeptide A (POLR3A)

RPC1; RPC155; hRPC155; RNA Polymerase III 155 kDa Subunit; DNA-directed RNA polymerase III subunit RPC1; DNA-directed RNA polymerase III largest subunit
RNA Polymerase III, DNA Directed Polypeptide A (POLR3A)
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition By similarity. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses.
Organism species: Homo sapiens (Human)
  • Protein RPS062Hu01Recombinant RNA Polymerase III, DNA Directed Polypeptide A (POLR3A)Customize
  • AntibodyPAS062Hu01Polyclonal Antibody to RNA Polymerase III, DNA Directed Polypeptide A (POLR3A)Customize
  • AntibodyMAS062Hu21Monoclonal Antibody to RNA Polymerase III, DNA Directed Polypeptide A (POLR3A)Customize
  • Assay KitSES062HuELISA Kit for RNA Polymerase III, DNA Directed Polypeptide A (POLR3A)Customize
  • Assay KitSCS062HuCLIA Kit for RNA Polymerase III, DNA Directed Polypeptide A (POLR3A)Customize
Organism species: Mus musculus (Mouse)
  • Protein RPS062Mu01Recombinant RNA Polymerase III, DNA Directed Polypeptide A (POLR3A)Customize
  • AntibodyPAS062Mu01Polyclonal Antibody to RNA Polymerase III, DNA Directed Polypeptide A (POLR3A)Customize
  • AntibodyMAS062Mu21Monoclonal Antibody to RNA Polymerase III, DNA Directed Polypeptide A (POLR3A)Customize
  • Assay KitSES062MuELISA Kit for RNA Polymerase III, DNA Directed Polypeptide A (POLR3A)Customize
  • Assay KitSCS062MuCLIA Kit for RNA Polymerase III, DNA Directed Polypeptide A (POLR3A)Customize
Organism species: Rattus norvegicus (Rat)
  • Protein RPS062Ra01Recombinant RNA Polymerase III, DNA Directed Polypeptide A (POLR3A)Customize
  • AntibodyPAS062Ra01Polyclonal Antibody to RNA Polymerase III, DNA Directed Polypeptide A (POLR3A)Customize
  • AntibodyMAS062Ra21Monoclonal Antibody to RNA Polymerase III, DNA Directed Polypeptide A (POLR3A)Customize
  • Assay KitSES062RaELISA Kit for RNA Polymerase III, DNA Directed Polypeptide A (POLR3A)Customize
  • Assay KitSCS062RaCLIA Kit for RNA Polymerase III, DNA Directed Polypeptide A (POLR3A)Customize
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