Regulator Of Ribosome Synthesis 1 (RRS1)

RRS1, a conserved essential gene, encodes a novel regulatory protein required for ribosome biogenesis in Saccharomyces cerevisiae.A secretory defect causes specific and significant transcriptional repression of both ribosomal protein and rRNA genes, suggesting the coupling of plasma membrane and ribosome syntheses. RRS1, which appeared to be defective in the signaling pathway. The rrs1-1 mutation greatly reduced transcriptional repression of both rRNA and ribosomal protein genes that is caused by a secretory defect. RRS1 is a novel, essential gene encoding a nuclear protein of 203 amino acid residues that is conserved in eukaryotes. A conditional rrs1-null mutant was constructed by placing RRS1 under the control of the GAL1 promoter.