RUN Domain Containing Protein 1 (RUNDC1)

RUN Domain Containing Protein 1 (RUNDC1)
The AWM predicted a triplet of closely associated genes: , BRCA1, and NBR1. BRCA1 and NBR1 are 55 kb apart and RUNDC1 is 92 kb from BRCA1 and 147 kb from NBR1. In the bovine genome, the extent of LD declines rapidly from 0 to 200 kb. There is previous evidence for BRCA1 and NBR1 interaction as they share the same bidirectional promoter region. However, the predicted interactions between RUNDC1 and BRCA1, as well as betweenRUNDC1andNBR1, are yet to be tested.RUNDC1 is an inhibitor of the tumor suppressor p53, a gene that embodies the link between oncogenes and reproduction. Evidence for coexpression of p53 and BRCA1 has been only very recently published. RUNDC1is a regulator of BRCA1, underscoring the power of the AWM for generating hypotheses.

Organism species: Homo sapiens (Human)

Organism species: Mus musculus (Mouse)

Organism species: Rattus norvegicus (Rat)