Rabphilin 3A (RPH3A)

RPH3A contains two C2 domains and binds calcium ions at low micromolar concentration. Rabphilin was shown to regulate neurotransmitter release in hippocampal neurons after neurons had an increased synaptic activity and their release rate was depressed.

The deduced 694-amino acid protein shares 86.9% identity over 703 amino acids with rat Rph3a. RT-PCR ELISA detected highest expression in fetal brain, followed by adult spinal cord and whole brain. Much lower expression was detected in adult lung, testis, and spleen. Expression was high in all specific adult brain regions tested, with highest abundance in subthalamic nuclei and thalamus