Ras Associating And Dilute Domain Containing Protein (RADIL)

The transcript contains repetitive elements in its 3-prime UTR, and the deduced 1,114-amino acid protein contains a RAS (HRAS)-association domain, a PDZ domain, and a DIL domain, suggesting it has a role in cell signaling. RT-PCR ELISA detected highest expression in adult brain, spinal cord, testis, and pancreas, moderate expression in heart, lung, skeletal muscle, ovary, and fetal brain, and low expression in spleen, kidney, and adult and fetal liver. Expression was moderate to high in all specific adult brain regions examined, with highest levels in cerebellum.

RADIL protein contains 1,075 amino acids.Knockdown of RADIL in mouse breast epithelial cells or human chondrosarcoma cells resulted in reduced cell adhesion or migration, respectively.