Ras Homolog Gene Family, Member J (RHOJ)

ARHJ belongs to the Rho family of small GTP-binding proteins. Rho proteins regulate the dynamic assembly of cytoskeletal components for several physiologic processes, such as cell proliferation and motility and the establishment of cell polarity. They are also involved in pathophysiologic process, such as cell transformation and metastasis. The deduced 214-amino acid human protein contains the canonical G1, G2, and G3 boxes involved in nucleotide binding, as well as a 2-cysteine box, which is a substrate for geranylgeranylation and farnesylation. The deduced mouse protein contains 204 amino acids and shares 93% amino acid identity with human ARHJ. Most differences between the human and mouse proteins are clustered within the N- and C-terminal ends. ARHJ also shares significant similarity with TC10 and CDC42.