Ras Suppressor Protein 1 (RSU1)

Ras suppressor protein 1 is a protein that is involved in the Ras signal transduction pathway, growth inhibition, and nerve-growth factor induced differentiation processes, as determined in mouse and human cell line studies. In mouse, the encoded protein was initially isolated based on its ability to inhibit v-Ras transformation. Multiple alternatively spliced transcript variants for this gene have been reported; one of these variants was found only in glioma tumors.

Rsu1 (formerly referred to as Rsp1), a novel cDNA capable of suppressing Ki-ras transformation. human RSU1 cDNA from a lambda gt10 primary skin fibroblast cDNA library and showed that the human protein exhibits more than 95% conservation with the murine Rsu1 protein.