RecQ Protein Like Protein (RECQL)

RECQL is a member of the RecQ DNA helicase family. DNA helicases are enzymes involved in various types of DNA repair, including mismatch repair, nucleotide excision repair and direct repair. Some members of this family are associated with genetic disorders with predisposition to malignancy and chromosomal instability. The biological function of this helicase has not yet been determined. Two alternatively spliced transcripts, which encode the same isoform but differ in their 5' and 3' UTRs, have been described.

RECQL gene was regionalized to 12p12-p11. The corresponding mouse gene, Recql, was mapped to the telomeric region of mouse chromosome 6 by analysis of DNA from an interspecific cross.