Receptor Accessory Protein 6 (REEP6)

Dp1l1 is a membrane protein that likely plays a role in intracellular membrane trafficking in RGCs.The deduced 201-amino acid protein shares 57% identity with mouse and human DP1 (DP1). Northern blot analysis detected high expression of Dp1l1 in mouse retina and liver, with lower levels in kidney and testis, and RT-PCR showed low expression in spleen and lung. No expression was detected in brain.

In situ hybridization and immunohistochemical analyses showed that Dp1l1 mRNA and protein were localized richly in retinal ganglion cells (RGCs). Dp1l1 was present in the cytoplasm in a punctate pattern.In situ hybridization of mouse olfactory epithelium revealed expression of Reep6 in supporting cells, but not in olfactory neurons.