Recombination Activating Gene 1 (RAG1)

RNF74; RING Finger Protein 74; V(D)J Recombination-Activating Protein 1; Endonuclease RAG1; E3 ubiquitin-protein ligase RAG1
Recombination Activating Gene 1 (RAG1)
Nucleotide sequencing of human and mouse RAG1 cDNA clones encode predicted 119-kD proteins of 1,043 and 1,040 amino acids, respectively, with 90% sequence identity. The RAG1 gene has been conserved between species that carry out the V(D)J recombination, and its pattern of expression correlates exactly with the pattern of expression of V(D)J recombinase activity. Oettinger et al. (1990) gave a corrected length of 6.6 kb for the RAG1 cDNA.
RAG1 is critical for joining in vivo and strongly suggesting that the postcleavage complex is important in end joining. The E423Q mutant was severely defective for both hairpin opening in vitro and coding joint formation in vivo. These data suggested that the hairpin opening activity of the RAG proteins plays an important physiologic role in V(D)J recombination.
Organism species: Homo sapiens (Human)
  • Protein RPH268Hu01Recombinant Recombination Activating Gene 1 (RAG1)Customize
  • AntibodyPAH268Hu01Polyclonal Antibody to Recombination Activating Gene 1 (RAG1)Customize
  • AntibodyMAH268Hu21Monoclonal Antibody to Recombination Activating Gene 1 (RAG1)Customize
  • Assay KitSEH268HuELISA Kit for Recombination Activating Gene 1 (RAG1)Customize
  • Assay KitSCH268HuCLIA Kit for Recombination Activating Gene 1 (RAG1)Customize
Organism species: Mus musculus (Mouse)
  • Protein RPH268Mu01Recombinant Recombination Activating Gene 1 (RAG1)Customize
  • AntibodyPAH268Mu01Polyclonal Antibody to Recombination Activating Gene 1 (RAG1)Customize
  • AntibodyMAH268Mu21Monoclonal Antibody to Recombination Activating Gene 1 (RAG1)Customize
  • Assay KitSEH268MuELISA Kit for Recombination Activating Gene 1 (RAG1)Customize
  • Assay KitSCH268MuCLIA Kit for Recombination Activating Gene 1 (RAG1)Customize
Organism species: Rattus norvegicus (Rat)
  • Protein RPH268Ra01Recombinant Recombination Activating Gene 1 (RAG1)Customize
  • AntibodyPAH268Ra01Polyclonal Antibody to Recombination Activating Gene 1 (RAG1)Customize
  • AntibodyMAH268Ra21Monoclonal Antibody to Recombination Activating Gene 1 (RAG1)Customize
  • Assay KitSEH268RaELISA Kit for Recombination Activating Gene 1 (RAG1)Customize
  • Assay KitSCH268RaCLIA Kit for Recombination Activating Gene 1 (RAG1)Customize
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