Regulator Of G Protein Signaling 11 (RGS11)

RGS11 belongs to the RGS (regulator of G protein signaling) family. Members of the RGS family act as GTPase-activating proteins on the alpha subunits of heterotrimeric, signal-transducing G proteins. This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified.The predicted 467-amino acid human protein contains a DEP (Dishevelled, EGL-10, pleckstrin) domain and an RGS domain. In addition, sequence analysis revealed that RGS11, RGS6 , RGS7, RGS9, and C. elegans EGL-10 all contain a conserved 64-amino acid region that the authors called a GGL domain because of its similarity to G protein gamma subunits.