Regulatory Factor X 4 (RFX4)

RFX4 is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X2, X3, and X5. It has been shown to interact with itself as well as with regulatory factors X2 and X3, but it does not interact with regulatory factor X1. This protein may be a transcriptional repressor rather than a transcriptional activator. Three transcript variants encoding different isoforms have been described for this gene.One cDNA, clone 24, contained the first 3 exons of the ESR1 gene followed by a unique sequence. RNase protection studies indicated that clone 24 mRNA was present in only 1 of 61 breast cancer biopsy samples tested.