Regulatory Factor X 6 (RFX6)

RFX6 is a member of the regulatory factor X (RFX) family of transcription factors. The deduced 928-amino acid protein is a member of the winged helix family of DNA-binding proteins with high similarity over the DBDs and highest overall similarity to RFX4.

RFX6 contains a winged helix region, predicted to interact with the major groove of DNA, and a conserved helix H3 predicted to interact with the minor groove. EST database analysis showed expression of RFX6 primarily in pancreas with lower expression in liver, which was confirmed by analysis of mouse SAGE libraries. RFX6 interacted with RFX family members RFX2 and RFX3, in addition to interactions with DTX1, DTX2 , FHL3 , CCNK, and SS18L1.