Relaxin Receptor 2 (RXFP2)

Relaxin/insulin-like family peptide receptor 2, also known as RXFP2, is a G-protein coupled receptor.The receptors for glycoprotein hormones such as follicle-stimulating hormone and thyroid-stimulating hormoneare G protein-coupled, 7-transmembrane receptors (GPCRs) with large N-terminal extracellular domains. Leucine-rich repeat (LRR)-containing GPCRs (LGRs) form a subgroup of the GPCR superfamily.Expression of LGR8 with a mutation in transmembrane domain 6 (asp647 to tyr), but not of wildtype LGR8, resulted in increased basal production of cAMP, as seen in similar experiments with LGR7. Treatment of cells expressing LGR7 or LGR8 with pig relaxin resulted in a dose-dependent increase in cAMP production. In contrast, treatment with insulin was ineffective.