Retinitis Pigmentosa GTPase Regulator (RPGR)

CRD; COD1; CORDX1; PCDX; RP15; RP3; XLRP3; Orf15; Retinitis Pigmentosa 15; Cone Dystrophy 1(X-Linked); X-linked retinitis pigmentosa GTPase regulator
Retinitis Pigmentosa GTPase Regulator (RPGR)
RPGR encodes a protein with a series of six RCC1-like domains, characteristic of the highly conserved guanine nucleotide exchange factors. Mutations in this gene have been associated with X-linked retinitis pigmentosa (XLRP). Multiple alternatively spliced transcript variants that encode different isoforms of this gene have been reported, but the full-length natures of only some have been determined.The predicted 90-kD RPGR protein contains in its N-terminal half a tandem repeat structure highly similar to the regulator of chromosome condensation (RCC1), which regulates the GTPase RAN. The C terminus of the protein contains a cluster of basic residues followed by a consensus isoprenylation site. The authors noted that confirmation of the isoprenylation of this site would establish a novel means of membrane anchorage for a GTPase regulator.
Organism species: Homo sapiens (Human)
  • Protein RPF777Hu01Recombinant Retinitis Pigmentosa GTPase Regulator (RPGR)Customize
  • AntibodyPAF777Hu01Polyclonal Antibody to Retinitis Pigmentosa GTPase Regulator (RPGR)Customize
  • AntibodyMAF777Hu21Monoclonal Antibody to Retinitis Pigmentosa GTPase Regulator (RPGR)Customize
  • Assay KitSEF777HuELISA Kit for Retinitis Pigmentosa GTPase Regulator (RPGR)Customize
  • Assay KitSCF777HuCLIA Kit for Retinitis Pigmentosa GTPase Regulator (RPGR)Customize
Organism species: Mus musculus (Mouse)
  • Protein RPF777Mu01Recombinant Retinitis Pigmentosa GTPase Regulator (RPGR)Customize
  • AntibodyPAF777Mu01Polyclonal Antibody to Retinitis Pigmentosa GTPase Regulator (RPGR)Customize
  • AntibodyMAF777Mu21Monoclonal Antibody to Retinitis Pigmentosa GTPase Regulator (RPGR)Customize
  • Assay KitSEF777MuELISA Kit for Retinitis Pigmentosa GTPase Regulator (RPGR)Customize
  • Assay KitSCF777MuCLIA Kit for Retinitis Pigmentosa GTPase Regulator (RPGR)Customize
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