Rho GTPase Activating Protein 11A (ARHGAP11A)

By sequencing clones obtained from a size-fractionated immature myeloid leukemia cell line cDNA library, Nomura et al. (1994) cloned ARHGAP11A, which they designated KIAA0013. The cDNA contains a repetitive element at its 3-prime end, and the deduced 1,023-amino acid protein has a rhoGAP domain and a putative tyrosine phosphorylation site. Northern blot analysis detected highest expression in thymus, intermediate expression in placenta, kidney, testis, and colon, weak expression in heart, brain, lung, liver, skeletal muscle, pancreas, spleen, ovary, small intestine, and peripheral blood leukocytes, and none in prostate. Nomura et al. (1994) presented sequence features, including hydrophobicity/hydrophilicity and regions of similarity to other known genes, of genes identified by Nomura et al. (1994).